Structured Peptide Library

Overview

Since HiPep Laboratories founding in 2002, we provide structured peptide libraries constructed as capture molecules equipped with biochips. These peptide libraries have the potential to inhibit protein-protein interactions and change protein function. Number of possible design peptides: de novo designed peptides ca. 500 species of α-helix, ca. 400 species of β-sheet, ca. 500 species of β-loop, ca. 100 glycopeptides; N-terminal TAMRA, C-terminal Cys, glycopeptide only Cys (Acm)

  1. High-purity peptides are pipetted into vials or tita-plates
  2. Hit peptides patents can also be monopolized by customers
  3. Structural optimization consulting based on hit sequence
  4. Synthesis of peptide libraries of optimized structures on a commission basis

Application: protein-protein interaction (PPI) inhibitor screening etc.

Tominaga, Y., Hirata, A., and Nokihara, K., Bioorg. Med. Chem. Lett. 25, 611-615, 2015.

Recognition of a monoclonal antibody against a small molecular weight antigen by monitoring the antigen–antibody reaction using fluorescence labeled structured peptides

Kawasaki, T., Ohyama, T., Hirata, A. and Nokihara, K., Bull. Chem. Soc. Jpn., 83, 799-801, 2010.

Fingerprint-detection of Sugar-Binding Proteins Generated by Labelled Structured Glycopeptides Arrays

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