Since HiPep Laboratories founding in 2002, we provide structured peptide libraries constructed as capture molecules equipped with biochips. These peptide libraries have the potential to inhibit protein-protein interactions and change protein function. Number of possible design peptides: de novo designed peptides ca. 500 species of α-helix, ca. 400 species of β-sheet, ca. 500 species of β-loop, ca. 100 glycopeptides; N-terminal TAMRA, C-terminal Cys, glycopeptide only Cys (Acm)
- High-purity peptides are pipetted into vials or tita-plates
- Hit peptides patents can also be monopolized by customers
- Structural optimization consulting based on hit sequence
- Synthesis of peptide libraries of optimized structures on a commission basis
Application: protein-protein interaction (PPI) inhibitor screening etc.
Tominaga, Y., Hirata, A., and Nokihara, K., Bioorg. Med. Chem. Lett. 25, 611-615, 2015.
Recognition of a monoclonal antibody against a small molecular weight antigen by monitoring the antigen–antibody reaction using fluorescence labeled structured peptides
Kawasaki, T., Ohyama, T., Hirata, A. and Nokihara, K., Bull. Chem. Soc. Jpn., 83, 799-801, 2010.
Fingerprint-detection of Sugar-Binding Proteins Generated by Labelled Structured Glycopeptides Arrays