Peptide-Vehicle Library

Overview

In the three years from FY 2008 to FY 2010, we promoted Okinawa Innovation Research Consignment Project “Developing cancer therapeutic drugs and test methods using peptide libraries”. We designed a peptide-vehicle in which a cell surface recognition peptide, a cell penetrating peptide and an anticancer agent are conjugated as a candidate substance for “cell targeting therapeutic drug”, and studied to construct a library. We will provide “Peptide-Vehicle Library” constructed based on the results. In recent years, problems such as QOL decrease due to side effects, patent disappearance of anticancer substances are a problem, and it is expected that drugs will be delivered that anticancer drugs specifically to cancer cells. We hope to use it as a tool of drug discovery research.

Reference　Hirata, A., Nokihara, K. Construction of peptide-vehicles, bioconjugates having modules of cancer cell surface capture and cell-penetrating peptide with anticancer agents, Tetrahedron Lett.　2014, 55, 4091-4094.